In the Enayati Lab, we use 3D printing, biomaterial functionalization, and encapsulation strategies to develop cardiovascular implants with tailored mechanical and biological properties, with a particular focus on hemocompatibility and cellular responses. Using predictive in vitro assessment models, we evaluate implant-induced immune responses and material biodegradation. These findings are then correlated with outcomes from small- and large-animal models to assess the predictive value and clinical relevance of our in vitro methods. Our aim is to design safe, functional implants that provide the required mechanical support while promoting tissue integration and regeneration.
Mission and Vision
One of our main missions is to develop biodegradable cardiovascular implants, including 3D-printed auxetic cardiac patches with controlled architectures and anisotropic mechanical properties, as well as biodegradable and antibacterial mitral annuloplasty rings. These implants are designed to provide the required mechanical support, degrade gradually, and, where applicable, reduce the risk of implant-associated infection.
Biofunctionalisation, encapsulation, and nano- and micropatterning strategies are used to incorporate extracellular matrix components and bioactive molecules, such as nitric oxide donors, and to modify implant surface topography. These approaches aim to improve cellular responses, hemocompatibility, tissue integration, and regeneration.
To improve implant assessment before in vivo studies, we establish predictive, cell-based in vitro models that reproduce physiologically relevant conditions and evaluate implant-induced inflammatory and immune responses, as well as material biodegradation.