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Reasearch Group Podesser & Kiss

  1. Center for Biomedical Research and Translational Surgery
  2. Research
  3. Cardiovascular Institute
  4. Research Groups
  5. Reasearch Group Podesser & Kiss

Cardiac Pressure and Volume Overload

Over the last few years, we established small and large animal models to better understand the molecular mechanisms underlying pressure and volume overload induced left ventricular hypertrophy and dysfunction. Main focus of our lab is to characterize the molecular phenotype and functionality of Tenascin-C across cardiac fibrosis, endothelial dysfunction and cardiomyocytes dysfunction.

Myocardial Protection

Besides the chronic adaptation and changes of cardiac function due to pressure or volume overload, we investigate the mechanism and target signalling pathways that play a role in myocardial ischemia and reperfusion injury. These studies are performed in primary cardiomyocytes as well as in small and large animal models of myocardial ischemia and reperfusion in vivo (cardiopulmonary bypass and ST-elevation myocardial infarction) and ex vivo (isolated heart).

Vascular Function Studies

Our laboratory is interested in understanding vascular endothelial function in chronic disease. Our long term goal is to characterize and better understand mechanism that play a dominant role in endothelial cell dysfunction (redox signalling imbalance, endothelial and cardiomyocytes combination and interaction in various forms of cardiovascular disease). We are working with HUVEC and isolated primary endothelial cells. Vascular function is assessed on human, rats, and mouse vessel segments by wire myograph.
  • Michael Fischer — Center for Physiology and Pharmacology, Institute of Physiology, Medical University of Vienna
  • Karlheinz Hilber — Department of Neurophysiology and -pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
  • Xaver Köenig — Department of Neurophysiology and -pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
  • Dietmar Abraham — Center for Anatomy and Cell Biology, Medical University Vienna
  • Dimitrios Tsiantoulas — Department of Laboratory Medicine, Medical University of Vienna
  • Marcus Hacker, Xiang Li — Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna
  • Thomas H Helbich, Joachim Friske, Thomas Wanek — Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna
  • Ludwig Boltzmann Institute for Cardiovascular Research  (Heinz Schima, Helga Bergmeister, Johann Wojta and Kurt Huber)

 

  • David Chambers — Cardiac Surgery/Cardiac Surgical Research, The Rayne Institute (King's College London), Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, UK
  • Stefan Chlopicki — Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Medical College
  • Zoltan Papp, Attila Tóth — Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Hungary
  • Francesco Paneni — University of Zurich Center for Molecular Cardiology
  • Anna Marsano — Departments of Biomedicine and Surgery, University Basel and University Hospital Basel, Switzerland
  • Zoltan Jakus, György Nádasy — Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary
  • Florence Pinet — Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France
  • Manuel Mayr — King's British Heart Foundation Centre, King's College London, 125 Coldharbour Ln, SE5 9NU London, UK
  • Márta Sárközy — Interdisciplinary Center of Excellence and MEDICS Research Group, Department of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, Hungary.